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This Psalm gives us the solitary musing of a godly soul over the atheism of the world. He recites God’s verdict (w. 3-4) upon man after making a solemn inquisition (such as He made of old at Babel and at Sodom, Gen. 11. 5; 18. 21) – then anticipates the confusion of the children of men, when God shows Himself in the midst of His generation (thus morally opposed to the generation of Psalm 12. 7-8), and closes with uttering a desire for that occasion.
The apostle can quote this Psalm when describing men in Romans 3. For all of us by nature had the mind of the atheist – alienated from the life of God. – J. G. Bellett, Meditations on the Psalms.